Selective membrane protein trafficking: vectorial flow and filter

Trends Biochem Sci. 1992 Jan;17(1):27-32. doi: 10.1016/0968-0004(92)90423-7.


Membrane proteins trafficking along cellular pathways encounter molecular filters. These filters can introduce them to new pathways and thus direct them towards new destinations. Many proteins carry molecular signals within their cytoplasmic domains that allow them to be selected by the filters. The detailed characterization of these signals is providing new insights into the pathways themselves and indicating the locations of other, as yet unidentified filters.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biological Transport, Active
  • Cell Line
  • Cell Membrane / physiology
  • Clathrin / physiology
  • Golgi Apparatus / physiology
  • Membrane Proteins / metabolism*
  • Molecular Sequence Data
  • Protein Processing, Post-Translational / physiology*
  • Signal Transduction / physiology


  • Clathrin
  • Membrane Proteins