Rapid Inversion of the Prevalences of Macrolide Resistance Phenotypes Paralleled by a Diversification of T and Emm Types Among Streptococcus Pyogenes in Portugal

Antimicrob Agents Chemother. 2005 May;49(5):2109-11. doi: 10.1128/AAC.49.5.2109-2111.2005.

Abstract

In Portugal erythromycin resistance of 26.6% (n = 352) remained constant during 1998 to 2003, however in 1998 the MLS(B) phenotype dominated (85%), whereas in 2003 the M phenotype prevailed (77%). A decline in T12/emm22 MLS(B) isolates could partially explain the drop in this phenotype, but the rise of the M phenotype was not due to clonal expansion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics*
  • Drug Resistance, Bacterial
  • Humans
  • Macrolides / pharmacology*
  • Membrane Proteins / genetics*
  • Phenotype
  • Portugal / epidemiology
  • Streptococcal Infections / drug therapy
  • Streptococcal Infections / epidemiology
  • Streptococcal Infections / microbiology
  • Streptococcus pyogenes / drug effects*
  • Streptococcus pyogenes / genetics*
  • Tetracycline Resistance

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Emm22 protein,Streptococcus pyogenes
  • Macrolides
  • Membrane Proteins