Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 May;49(5):2119-21.
doi: 10.1128/AAC.49.5.2119-2121.2005.

Differences in Interactions Between Azole Drugs Related to Modifications in the 14-alpha Sterol Demethylase Gene (cyp51A) of Aspergillus Fumigatus

Affiliations
Free PMC article

Differences in Interactions Between Azole Drugs Related to Modifications in the 14-alpha Sterol Demethylase Gene (cyp51A) of Aspergillus Fumigatus

G Garcia-Effron et al. Antimicrob Agents Chemother. .
Free PMC article

Abstract

The combined activity of different azole drugs was investigated. Thirty-one Aspergillus fumigatus strains were tested, including two cyp51A(-) and one cyp51B(-) gene-knockout strain and azole-susceptible and -resistant strains with different resistance mechanisms. The combination of itraconazole and voriconazole was synergistic for all strains except for those with gene knockouts.

Similar articles

See all similar articles

Cited by 16 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback