Hypothalamic sensing of fatty acids

Nat Neurosci. 2005 May;8(5):579-84. doi: 10.1038/nn1456.


Selective regions of the brain, including the hypothalamus, are capable of gathering information on the body's nutritional status in order to implement appropriate behavioral and metabolic responses to changes in fuel availability. This review focuses on direct metabolic signaling within the hypothalamus. There is growing evidence supporting the idea that fatty acid metabolism within discrete hypothalamic regions can function as a sensor for nutrient availability that can integrate multiple nutritional and hormonal signals.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acyl Coenzyme A / metabolism
  • Animals
  • Appetite Regulation / physiology*
  • Energy Metabolism / physiology*
  • Fatty Acids / metabolism*
  • Feedback, Physiological / physiology*
  • Humans
  • Hypothalamus / physiology*
  • Insulin Resistance / physiology
  • Obesity / metabolism
  • Obesity / physiopathology
  • Signal Transduction / physiology


  • Acyl Coenzyme A
  • Fatty Acids