C-glycosylflavones from the aerial parts of Eleusine indica inhibit LPS-induced mouse lung inflammation

Planta Med. 2005 Apr;71(4):362-3. doi: 10.1055/s-2005-864104.

Abstract

The infusion of aerial parts (EI) of Eleusine indica Gaertn (Poaceae) is used in Brazil against airway inflammatory processes like influenza and pneumonia. Pre-treatment with 400 mg/kg of crude extract inhibited 98% of lung neutrophil recruitment in mice exposed to aerosols of lipopolysaccharide (LPS) from Gram-negative bacteria, in a dose-dependent manner. At 400 microg/kg, schaftoside (6-C-beta-glucopyranosyl-8-C-alpha-arabinopyranosylapigenin) and vitexin (8-C-beta-glucopyranosylapigenin), isolated from EI, inhibited 62% and 80% of lung neutrophil influx, respectively. These results may justify the popular use of E. indica against airway inflammatory processes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Dose-Response Relationship, Drug
  • Eleusine*
  • Flavones / administration & dosage
  • Flavones / pharmacology
  • Flavones / therapeutic use
  • Lipopolysaccharides
  • Lung Diseases / chemically induced
  • Lung Diseases / drug therapy*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Phytotherapy*
  • Plant Components, Aerial
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Flavones
  • Lipopolysaccharides
  • Plant Extracts