Anti-HIV protease activity from rosa family plant extracts and rosamultin from Rosa rugosa

J Med Food. 2005 Spring;8(1):107-9. doi: 10.1089/jmf.2005.8.107.

Abstract

To identify substances with anti-human immunodeficiency virus (HIV) activity from plant sources, 12 extracts of Rosa family plants were screened for their inhibitory effects against HIV-1 protease. Of the extracts tested, the strongest inhibitory effects were observed in the root of Rosa rugosa and the leaves of Prunus sargentii, at a concentration of 100 microg/mL. Rosamultin isolated from the root of R. rugosa inhibited HIV-1 protease by 53% at a concentration of 100 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / pharmacology
  • Anti-HIV Agents / therapeutic use
  • Chromatography, High Pressure Liquid
  • Dose-Response Relationship, Drug
  • HIV Infections / drug therapy*
  • HIV Protease / drug effects
  • HIV Protease / metabolism
  • HIV Protease Inhibitors / pharmacology
  • HIV Protease Inhibitors / therapeutic use*
  • HIV-1* / enzymology
  • HIV-1* / genetics
  • Humans
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Rosa / chemistry*
  • Treatment Outcome
  • Triterpenes / pharmacology
  • Triterpenes / therapeutic use*

Substances

  • Anti-HIV Agents
  • HIV Protease Inhibitors
  • Plant Extracts
  • Triterpenes
  • rosamultin
  • HIV Protease