Class-III Malocclusion: Genetics or Environment? A Twins Study

J Indian Soc Pedod Prev Dent. 2005 Mar;23(1):27-30. doi: 10.4103/0970-4388.16023.


Etiology of class-III malocclusion is generally believed to be genetic. A wide range of environmental factors have been suggested as contributing factors for the development of class-III malocclusion. Twin study is one of the most effective methods available for investigating genetically determined variables of malocclusion. Discordancy for class-III malocclusion is a frequent finding in dizygotic twins. However, class-III malocclusion discordancy in monozygotic twins is a rare finding. The purpose of this study of monozygotic twins is to assess the genetic and environmental components of variation within the cranio-dento-facial complex.

Publication types

  • Case Reports
  • Twin Study

MeSH terms

  • Cephalometry
  • Diseases in Twins / etiology
  • Diseases in Twins / genetics*
  • Female
  • Gene-Environment Interaction*
  • Humans
  • Malocclusion, Angle Class III / etiology
  • Malocclusion, Angle Class III / genetics*
  • Maxillofacial Development / genetics*
  • Severity of Illness Index
  • Twins, Monozygotic*