Large or multiple congenital melanocytic nevi: occurrence of cutaneous melanoma in 1008 persons

J Am Acad Dermatol. 2005 May;52(5):793-7. doi: 10.1016/j.jaad.2005.02.024.


Background: There is a dearth of information regarding the occurrence of cutaneous melanoma in a large cohort of persons with large congenital melanocytic nevi (LCMN) or multiple congenital melanocytic nevi (MCMN).

Objective: The purpose of this article is to report our experience with 1008 persons having LCMN and MCMN.

Methods: Information was evaluated that was obtained from a database of persons with LCMN or MCMN voluntarily submitted by the affected persons to a nevus support group, the Nevus Network.

Results: Of those with garment LCMN, 2.9% developed cutaneous melanoma associated with 0.8% deaths. Of those with LCMN on the head or extremity, 0.3% developed cutaneous melanoma associated with no deaths to date. Of the small number with MCMN without a giant nevus, 6.7% developed cutaneous melanoma.

Limitations: Attending physician confirmation of submitted information was unavailable. Conclusions LCMN and MCMN were associated with a low occurrence of cutaneous melanoma in our group.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Cohort Studies
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Melanoma / etiology*
  • Melanosis / complications
  • Neurocutaneous Syndromes / complications
  • Nevus, Pigmented / complications
  • Nevus, Pigmented / congenital*
  • Nevus, Pigmented / therapy
  • Pregnancy
  • Pregnancy Complications, Neoplastic
  • Self-Help Groups / statistics & numerical data
  • Skin Neoplasms / etiology*