Safety and efficacy of an attenuated strain of Salmonella choleraesuis for vaccination of swine

Am J Vet Res. 1992 Apr;53(4):444-8.


The purpose of this study was to determine the safety and efficacy of a live Salmonella choleraesuis immunizing strain, obtained by repeated ingestion and recovery through porcine neutrophils. The strain was tested in mice and in pigs. The vaccine was safe and effective in controlled experimental trials, using clinical, pathologic, and microbiologic criteria. Vaccinated pigs were able to maintain normal weight gains during the 4-week observation period following challenge inoculation with a high dose of a virulent strain.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Bacterial Vaccines* / adverse effects
  • Body Temperature
  • Body Weight
  • Dose-Response Relationship, Immunologic
  • Female
  • Mice
  • Salmonella / immunology*
  • Salmonella / pathogenicity
  • Salmonella Infections, Animal / prevention & control*
  • Spleen / microbiology
  • Swine
  • Swine Diseases / prevention & control*
  • Vaccination / veterinary*
  • Vaccines, Attenuated / adverse effects
  • Virulence


  • Bacterial Vaccines
  • Vaccines, Attenuated