Yeast as a model for medical and medicinal research

Trends Pharmacol Sci. 2005 May;26(5):265-73. doi: 10.1016/j.tips.2005.03.004.

Abstract

In the past, studies using the yeast Saccharomyces cerevisiae enabled major breakthroughs in the understanding of basic cellular and molecular processes. Today, the use of yeast is undergoing a "rebirth" in both fundamental and applied research. Indeed, advances in yeast technology have paved the way for a variety of new genome-wide screening approaches. Experimental strategies using yeast aim to unravel disease-related molecular events and to discover novel medicinal compounds. In this article, the impact of yeast as an experimental tool for disease-related studies is summarized and the use of yeast in high-throughput screenings for pharmacological purposes is evaluated. The recently applied and promising approach of so-called humanized yeast systems is also discussed.

Publication types

  • Review

MeSH terms

  • Biomedical Research / methods*
  • Genome, Fungal
  • Models, Biological*
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism
  • Saccharomyces cerevisiae* / genetics
  • Saccharomyces cerevisiae* / metabolism
  • Saccharomyces cerevisiae* / physiology

Substances

  • Saccharomyces cerevisiae Proteins