A renaissance in trace amines inspired by a novel GPCR family
- PMID: 15860375
- DOI: 10.1016/j.tips.2005.03.007
A renaissance in trace amines inspired by a novel GPCR family
Abstract
Trace amines (TAs) are endogenous compounds that are related to biogenic amine neurotransmitters and are present in the mammalian nervous system in trace amounts. Although their pronounced pharmacological effects and tight link to major human disorders such as depression and schizophrenia have been studied for decades, the understanding of their molecular mode of action remained incomplete because of the apparent absence of specialized receptors. However, the recent discovery of a novel family of G-protein-coupled receptors (GPCRs) that includes individual members that are highly specific for TAs indicates a potential role for TAs as vertebrate neurotransmitters or neuromodulators, although the majority of these GPCRs so far have not been demonstrated to be activated by TAs. The unique pharmacology and expression pattern of these receptors make them prime candidates for targets in drug development in the context of several neurological diseases. Current research focuses on dissecting their molecular pharmacology and on the identification of endogenous ligands for the apparently TA-insensitive members of this receptor family.
Similar articles
-
Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.Genomics. 2005 Mar;85(3):372-85. doi: 10.1016/j.ygeno.2004.11.010. Genomics. 2005. PMID: 15718104
-
The potential of trace amines and their receptors for treating neurological and psychiatric diseases.Rev Recent Clin Trials. 2007 Jan;2(1):3-19. doi: 10.2174/157488707779318107. Rev Recent Clin Trials. 2007. PMID: 18473983 Review.
-
Biochemistry and molecular biology of receptors for biogenic amines in locusts.Microsc Res Tech. 2002 Feb 1;56(3):237-47. doi: 10.1002/jemt.10027. Microsc Res Tech. 2002. PMID: 11810725 Review.
-
Trace amines: identification of a family of mammalian G protein-coupled receptors.Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):8966-71. doi: 10.1073/pnas.151105198. Epub 2001 Jul 17. Proc Natl Acad Sci U S A. 2001. PMID: 11459929 Free PMC article.
-
The emerging roles of human trace amines and human trace amine-associated receptors (hTAARs) in central nervous system.Biomed Pharmacother. 2016 Oct;83:439-449. doi: 10.1016/j.biopha.2016.07.002. Epub 2016 Jul 15. Biomed Pharmacother. 2016. PMID: 27424325 Review.
Cited by
-
Psychedelics and schizophrenia: a double-edged sword.Mol Psychiatry. 2024 Sep 18. doi: 10.1038/s41380-024-02743-x. Online ahead of print. Mol Psychiatry. 2024. PMID: 39294303 Review.
-
Ligand recognition and G-protein coupling of trace amine receptor TAAR1.Nature. 2023 Dec;624(7992):672-681. doi: 10.1038/s41586-023-06804-z. Epub 2023 Nov 7. Nature. 2023. PMID: 37935376
-
Expression Pattern of Trace Amine-Associated Receptors during Differentiation of Human Pluripotent Stem Cells to Dopaminergic Neurons.Int J Mol Sci. 2023 Oct 18;24(20):15313. doi: 10.3390/ijms242015313. Int J Mol Sci. 2023. PMID: 37894992 Free PMC article.
-
Applications and Potential of In Silico Approaches for Psychedelic Chemistry.Molecules. 2023 Aug 9;28(16):5966. doi: 10.3390/molecules28165966. Molecules. 2023. PMID: 37630218 Free PMC article. Review.
-
Ulotaront: review of preliminary evidence for the efficacy and safety of a TAAR1 agonist in schizophrenia.Eur Arch Psychiatry Clin Neurosci. 2023 Oct;273(7):1543-1556. doi: 10.1007/s00406-023-01580-3. Epub 2023 May 10. Eur Arch Psychiatry Clin Neurosci. 2023. PMID: 37165101 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
