FGF signaling in flies and worms: more and more relevant to vertebrate biology

Cytokine Growth Factor Rev. 2005 Apr;16(2):151-8. doi: 10.1016/j.cytogfr.2005.03.002. Epub 2005 Mar 26.


FGF signaling in the invertebrate model systems Drosophila melanogaster and Caenorhabditis elegans was initially most obviously involved in cell motility events. More recently, however, FGFs and FGF signaling in these systems have been shown to affect many additional cellular processes. This recent work has shown that the pleiotropies of these FGF receptors resemble those of their vertebrate counterparts, and, in many cases, serve as excellent models for understanding the fundamental molecular mechanisms controlling these events.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alternative Splicing
  • Animals
  • Caenorhabditis elegans / physiology*
  • Cell Differentiation / physiology
  • Cell Movement / physiology
  • Drosophila melanogaster / physiology*
  • Fibroblast Growth Factors / physiology*
  • Gene Expression Regulation, Developmental
  • Homeostasis / physiology
  • Ligands
  • Models, Biological
  • Receptors, Fibroblast Growth Factor / physiology
  • Sex Differentiation / physiology
  • Signal Transduction / physiology*


  • Ligands
  • Receptors, Fibroblast Growth Factor
  • Fibroblast Growth Factors