Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

Cytokine Growth Factor Rev. 2005 Apr;16(2):159-78. doi: 10.1016/j.cytogfr.2005.01.004. Epub 2005 Feb 2.


Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert their pro-angiogenic activity by interacting with various endothelial cell surface receptors, including tyrosine kinase receptors, heparan-sulfate proteoglycans, and integrins. Their activity is modulated by a variety of free and extracellular matrix-associated molecules. Also, the cross-talk among FGFs, vascular endothelial growth factors (VEGFs), and inflammatory cytokines/chemokines may play a role in the modulation of blood vessel growth in different pathological conditions, including cancer. Indeed, several experimental evidences point to a role for FGFs in tumor growth and angiogenesis. This review will focus on the relevance of the FGF/FGF receptor system in adult angiogenesis and its contribution to tumor vascularization.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endothelial Cells / physiology
  • Fibroblast Growth Factor 2 / physiology
  • Fibroblast Growth Factors / physiology*
  • Genetic Therapy
  • Heparan Sulfate Proteoglycans / physiology
  • Heparin / physiology
  • Humans
  • Ischemia / therapy
  • Neoplasms / blood supply
  • Neovascularization, Pathologic / physiopathology*
  • Receptors, Fibroblast Growth Factor / physiology*
  • Receptors, Vascular Endothelial Growth Factor / physiology
  • Vascular Endothelial Growth Factor A / physiology


  • Heparan Sulfate Proteoglycans
  • Receptors, Fibroblast Growth Factor
  • Vascular Endothelial Growth Factor A
  • Fibroblast Growth Factor 2
  • Fibroblast Growth Factors
  • Heparin
  • Receptors, Vascular Endothelial Growth Factor