Fibroblast Growth Factor Signaling in Tumorigenesis

Cytokine Growth Factor Rev. 2005 Apr;16(2):179-86. doi: 10.1016/j.cytogfr.2005.01.003. Epub 2005 Feb 5.

Abstract

Fibroblast growth factors and their signaling receptors have been associated with multiple biological activities, including proliferation, differentiation and motility. Consequently, they have evoked interest as candidate oncogenes with the potential to initiate and/or promote tumorigenesis. This has resulted in a large literature describing the presence of these growth factors and their receptors in cancer cell lines and primary tumors of diverse origin. However, it is only recently that compelling evidence has emerged to implicate the fibroblast growth factors (Fgfs) and their receptors in the genesis of human cancers. Here, we outline the model systems that demonstrate the potential oncogenic nature of Fgf signaling and summarise recent evidence that implicates aberrant Fgf signaling as important in the natural history of some common human cancers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Female
  • Fibroblast Growth Factors / physiology*
  • Hematologic Neoplasms / etiology
  • Humans
  • Male
  • Mammary Neoplasms, Experimental / etiology
  • Neoplasms / etiology*
  • Prostatic Neoplasms / etiology
  • Receptor Protein-Tyrosine Kinases / physiology
  • Receptors, Fibroblast Growth Factor / physiology*
  • Signal Transduction / physiology*
  • Skin Neoplasms / etiology
  • Urologic Neoplasms / etiology

Substances

  • Receptors, Fibroblast Growth Factor
  • Fibroblast Growth Factors
  • Receptor Protein-Tyrosine Kinases