Immunotherapy and chemotherapy--a practical partnership

Nat Rev Cancer. 2005 May;5(5):397-405. doi: 10.1038/nrc1613.


This article discusses how recent data have altered the way we understand how dying tumour cells, particularly those killed by chemotherapy, engage with antitumour immune responses. These data have significant implications for the development of new protocols combining chemotherapy with immunotherapy, indicating an exciting potential for therapeutic synergy with general applicability to many cancer types.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, Neoplasm / immunology
  • Antineoplastic Agents / therapeutic use*
  • Apoptosis
  • CD8-Positive T-Lymphocytes / immunology
  • Combined Modality Therapy
  • Humans
  • Immunotherapy*
  • Mice
  • Neoplasms / therapy*


  • Antigens, Neoplasm
  • Antineoplastic Agents