Identification of MMP-1 as a putative breast cancer predictive marker by global gene expression analysis

Nat Med. 2005 May;11(5):481-3. doi: 10.1038/nm1243. Epub 2005 May 1.


Breast cancer is the second leading cause of cancer death for women in the United States. In 2005, about 215,000 cases of invasive breast cancer (IBC) and 50,000 cases of ductal carcinoma in situ will be diagnosed and 40,000 women will die of IBC in the US. Yet there is presently no molecular marker that can be used to detect a precancerous state or identify which premalignant lesions will develop into invasive breast cancer. Here we report the gene expression analysis of atypical ductal hyperplastic tissues from patients with and without a history of breast cancer. We identify MMP-1 as a candidate marker that may be useful for identification of breast lesions that can develop into cancer.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biomarkers, Tumor / genetics*
  • Breast Neoplasms / enzymology
  • Breast Neoplasms / genetics*
  • Carcinoma, Ductal, Breast / enzymology
  • Carcinoma, Ductal, Breast / genetics*
  • Female
  • Gene Expression Profiling*
  • Humans
  • Immunohistochemistry
  • Matrix Metalloproteinase 1 / genetics*
  • Oligonucleotide Array Sequence Analysis
  • RNA, Messenger / metabolism*
  • Reverse Transcriptase Polymerase Chain Reaction


  • Biomarkers, Tumor
  • RNA, Messenger
  • Matrix Metalloproteinase 1