May glutathione S-transferase M1 positive genotype afford protection against primary open-angle glaucoma?

Graefes Arch Clin Exp Ophthalmol. 2005 Apr;243(4):327-33. doi: 10.1007/s00417-004-1013-9. Epub 2004 Nov 17.


Purpose: To find out whether the polymorphism at GSTM1, GSTT1 and GSTP1 loci is associated with increased susceptibility to glaucoma.

Methods: We genotyped 153 primary open angle patients and 159 healthy controls. Genomic DNA from peripheral blood was examined using polymerase chain reaction and defined for the genetic polymorphisms of glutathione S-transferase.

Results: The frequency of the GSTM1 null genotype individuals among the glaucoma patients was significanlty higher than in controls (54.9 vs 40.9%) with odds ratio of 1.64 (95% CI: 1.10-2.59). The frequency of the GSTT1 and GSTP1 in both groups were not statistically different.

Conclusion: The present study suggests that the GSTM1 null genotype may be a genetic risk factor for development of primary open angle glaucoma. Further associations studies in other polymorphic genes for xenobiotic-metabolizing enzymes are needed to elucidate the environmental-genetic interaction in the underlying cause of primary open angle glaucoma.

MeSH terms

  • Adult
  • Aged
  • DNA Primers / chemistry
  • Female
  • Genotype
  • Glaucoma, Open-Angle / enzymology*
  • Glaucoma, Open-Angle / genetics*
  • Glutathione S-Transferase pi
  • Glutathione Transferase / genetics*
  • Humans
  • Intraocular Pressure
  • Isoenzymes / genetics
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Risk Factors


  • DNA Primers
  • Isoenzymes
  • glutathione S-transferase T1
  • GSTP1 protein, human
  • Glutathione S-Transferase pi
  • Glutathione Transferase
  • glutathione S-transferase M1