Hyperacute renal failure as the initial presentation of systemic lupus erythematosus

Lupus. 2005;14(4):331-3. doi: 10.1191/0961203305lu2070cr.


SLE nephritis is usually a slow process that may lead to renal failure many years after its first presentation. Success of different therapeutic modalities in preventing renal failure is therefore evaluated and compared only after many years of treatment. Lately, this conservative philosophy has been challenged with the acknowledgment of collapsing glomerulopathy (CG), a recent recognized clinical-pathological entity, characterized by rapidly progressive renal failure. Despite this ominous description we present an unusual case of a patient who presented with systemic lupus erythematosus (SLE) and clinical and pathological findings of CG, who completely remitted several weeks after commencing immunosuppressive therapy with intravenous cyclophosphamide and prednisolone.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / drug therapy
  • Acute Kidney Injury / etiology*
  • Acute Kidney Injury / immunology
  • Acute Kidney Injury / pathology
  • Adult
  • Cyclophosphamide / therapeutic use
  • Female
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / drug therapy
  • Lupus Nephritis / complications*
  • Lupus Nephritis / drug therapy
  • Lupus Nephritis / immunology
  • Lupus Nephritis / pathology
  • Microscopy, Electron
  • Prednisolone / therapeutic use
  • Remission Induction
  • Time Factors


  • Immunosuppressive Agents
  • Cyclophosphamide
  • Prednisolone