Abstract
Three exciting papers in this issue of Developmental Cell provide new insights into the regulation of chondrocytic, osteoblastic, and osteoclastic differentiation during skeletal development and postnatal growth. The studies demonstrate that Wnt/beta-catenin signaling represents both a mechanism in mesenchymal precursor cells for selecting between chondrocytic and osteoblastic fates as well as a mechanism in osteoblasts for stimulating the production of an inhibitor of osteoclast formation.
MeSH terms
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Animals
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Bone Development / genetics
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Bone Development / physiology*
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Cell Differentiation
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Chondrocytes / cytology
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Chondrocytes / metabolism
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Chondrogenesis
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Cytoskeletal Proteins / genetics
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Cytoskeletal Proteins / physiology*
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Intercellular Signaling Peptides and Proteins / genetics
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Intercellular Signaling Peptides and Proteins / physiology*
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Mice
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Osteoblasts / cytology
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Osteoblasts / metabolism
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Osteogenesis
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Signal Transduction
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Trans-Activators / genetics
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Trans-Activators / physiology*
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Wnt Proteins
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beta Catenin
Substances
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CTNNB1 protein, mouse
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Cytoskeletal Proteins
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Intercellular Signaling Peptides and Proteins
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Trans-Activators
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Wnt Proteins
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beta Catenin