SOX2 functions in adult neural stem cells

Trends Neurosci. 2005 May;28(5):219-21. doi: 10.1016/j.tins.2005.03.003.


Sox2 is expressed highly in the neuroepithelium of the developing CNS and has been shown to function in neural stem cells. Because Sox2-null mutant mice fail to develop beyond implantation, the role of SOX2 in the CNS has lacked validation. A new genetic model addresses the role of SOX2 in the adult brain and provides evidence that it is involved in the maintenance of neurons in specific regions, in the proliferation and/or maintenance of neural stem cells, and in neurogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Aging / physiology*
  • Animals
  • DNA-Binding Proteins / physiology*
  • HMGB Proteins / physiology*
  • Humans
  • Neurons / cytology
  • Neurons / physiology*
  • SOXB1 Transcription Factors
  • Stem Cells / cytology
  • Stem Cells / physiology*
  • Transcription Factors / physiology*


  • DNA-Binding Proteins
  • HMGB Proteins
  • SOX2 protein, human
  • SOXB1 Transcription Factors
  • Sox2 protein, mouse
  • Transcription Factors