Correlation of the Helicobacter pylori adherence factor BabA with duodenal ulcer disease in four European countries

FEMS Immunol Med Microbiol. 2005 May 1;44(2):151-6. doi: 10.1016/j.femsim.2004.10.010.


Helicobacter pylori strains harboring the vacAs1, cagA and babA2 have been associated with ulcer disease (UD). We compared the prevalence of these different genotypes and adhesive properties in H. pylori infected patients with UD in four European countries. Genomic DNA was isolated from 314 H. pylori strains: Germany (GER; n=92), Sweden (SWE, n=74), Portugal (POR, n=91) and Finland (FIN, n=57). The frequencies of babA2 genotype varied from 35% to 60%. Triple-positive strains (vacAs1+, cagA+ and babA2+) were significantly associated with UD in GER and POR and were closely correlated with UD in FIN, but not in SWE. Classification as triple-positive strains had a higher specificity for detection of UD in GER, POR and FIN than type1 or cagA+ strains. In vitro adhesion assays revealed that Swedish strains showed high adhesion properties and were thus correlated with the diagnosis of UD, although PCR detected the babA2 gene at lower frequencies and failed to show a correlation with UD. This finding appears to reflect allelic variations of the babA2 gene in SWE, although adhesive properties of the strains are retained.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesins, Bacterial / genetics
  • Adhesins, Bacterial / metabolism*
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Bacterial / genetics
  • Antigens, Bacterial / metabolism
  • Bacterial Adhesion*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Duodenal Ulcer / microbiology*
  • Duodenal Ulcer / physiopathology
  • Europe
  • Female
  • Genetic Variation
  • Genotype
  • Helicobacter Infections / microbiology*
  • Helicobacter Infections / physiopathology
  • Helicobacter pylori / classification
  • Helicobacter pylori / genetics
  • Helicobacter pylori / pathogenicity*
  • Helicobacter pylori / physiology
  • Humans
  • Lewis Blood Group Antigens / metabolism
  • Male
  • Middle Aged


  • Adhesins, Bacterial
  • Antigens, Bacterial
  • BabA protein, Helicobacter pylori
  • Bacterial Proteins
  • Lewis Blood Group Antigens
  • VacA protein, Helicobacter pylori
  • cagA protein, Helicobacter pylori