Whole-genome views of chromatin structure

Chromosome Res. 2005;13(3):289-98. doi: 10.1007/s10577-005-2166-z.

Abstract

DNA in eukaryotes is packed into chromatin. The basic component of chromatin is the nucleosome consisting of DNA wrapped around a histone octamer. Inside the cell nucleus, chromatin is folded into higher-order structures through various mechanisms, including repositioning of nucleosomes along the DNA, packing of nucleosomes into more condensed 3-dimensional configurations, looping of chromatin fibres, and tethering of chromosomal regions to nuclear structures. Over the past few years, new microarray-based methods have been developed for the genome-wide mapping of various aspects of chromatin structure. These methods are beginning to provide insights into the different types of chromatin and the architectural principles that govern the 3-dimensional organisation of the genome inside the nucleus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Nucleus / chemistry
  • Chromatin / chemistry*
  • Chromatin / genetics*
  • Chromosome Mapping*
  • Genome
  • Humans
  • Oligonucleotide Array Sequence Analysis*

Substances

  • Chromatin