Liquorice and hypertension

Neth J Med. 2005 Apr;63(4):119-20.

Abstract

Glycyrrhetinic acid, the active constituent of liquorice, inhibits renal IIbeta-hydroxysteroid dehydrogenase. This allows cortisol to stimulate mineralocorticoid receptors, which can result in hypertension and hypokalaemia. Treatment options are based on pathophysiological understanding.

Publication types

  • Editorial

MeSH terms

  • 11-beta-Hydroxysteroid Dehydrogenases / antagonists & inhibitors*
  • Candy / toxicity
  • Glycyrrhetinic Acid / toxicity*
  • Glycyrrhiza / chemistry
  • Glycyrrhiza / toxicity
  • Humans
  • Hypertension / chemically induced*
  • Hypertension / enzymology
  • Hypokalemia / chemically induced*
  • Hypokalemia / enzymology
  • Receptors, Mineralocorticoid / drug effects*

Substances

  • Receptors, Mineralocorticoid
  • 11-beta-Hydroxysteroid Dehydrogenases
  • Glycyrrhetinic Acid