Biomarkers for the detection and prognosis of prostate cancer

Curr Urol Rep. 2005 May;6(3):171-6. doi: 10.1007/s11934-005-0004-7.


Recent studies have cast doubt on the reliability of serum total prostate-specific antigen as a biomarker for the detection and prognosis of prostate cancer. Biomarkers that can identify those men at risk for clinically significant prostate cancer are desperately needed. The search for biomarkers that may improve the detection of biologically consequential prostate cancer is one of the most active areas under current investigation. In this review, we highlight some of these ongoing efforts. Proper validation of newly discovered biomarkers is of paramount importance.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / analysis*
  • Genetic Markers
  • Humans
  • Male
  • Prognosis
  • Prostate-Specific Antigen / blood
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / metabolism
  • Protein Isoforms / blood
  • Proteomics / methods
  • Racemases and Epimerases / urine


  • Biomarkers, Tumor
  • Genetic Markers
  • Protein Isoforms
  • Prostate-Specific Antigen
  • Racemases and Epimerases
  • alpha-methylacyl-CoA racemase