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, 66 (2-3), 129-36

The Olive Leaf Extract Exhibits Antiviral Activity Against Viral Haemorrhagic Septicaemia Rhabdovirus (VHSV)

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The Olive Leaf Extract Exhibits Antiviral Activity Against Viral Haemorrhagic Septicaemia Rhabdovirus (VHSV)

Vicente Micol et al. Antiviral Res.

Abstract

A commercial plant extract derived from olive tree leaf (Olea europaea) (LExt) and its major compound, oleuropein (Ole), inhibited the in vitro infectivity of the viral haemorrhagic septicaemia virus (VHSV), a salmonid rhabdovirus. Incubation of virus with LExt or Ole before infection reduced the viral infectivity to 10 and 30%, respectively. Furthermore, LExt drastically decreased VHSV titers and viral protein accumulation (virucidal effect) in a dose dependent manner when added to cell monolayers 36 h post-infection. On the other hand, both the LExt and Ole were able to inhibit cell-to-cell membrane fusion induced by VHSV in uninfected cells, suggesting interactions with viral envelope. Therefore, we propose that O. europaea could be used as a potential source of promising natural antivirals, which have demonstrated to lack impact on health and environment. In addition, Ole could be used to design other related antiviral agents.

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