Health effects classification and its role in the derivation of minimal risk levels: hepatic effects

Hana R Pohl; C-H Selene J Chou

doi:10.1016/j.yrtph.2005.03.002

Health effects classification and its role in the derivation of minimal risk levels: hepatic effects

Regul Toxicol Pharmacol. 2005 Jul;42(2):161-71. doi: 10.1016/j.yrtph.2005.03.002.

Authors

Hana R Pohl¹, C-H Selene J Chou

Affiliation

¹ Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA. hpohl@cdc.gov

PMID: 15869832
DOI: 10.1016/j.yrtph.2005.03.002

Abstract

The Agency for Toxic Substances and Disease Registry (ATSDR) derives health based guidance values called minimal risk levels (MRLs) to assist with assessment of risks posed by exposures to hazardous chemicals. Current MRLs are posted on ATSDR's web site (www.atsdr.cdc.gov). From the total 326 MRLs currently posted, 79 MRLs are based on hepatic endpoints. The paper reports on endpoints used for the derivation of these MRLs and the use of uncertainty factors. It also describes the ranking of effects into less serious and serious categories as described in ATSDR's Guidance for Developing Toxicological Profiles.

Publication types

Review

MeSH terms

Animals
Biliary Tract / drug effects
Biliary Tract / pathology
Guidelines as Topic
Hazardous Substances / administration & dosage
Hazardous Substances / classification
Hazardous Substances / toxicity
Humans
Liver / drug effects*
Liver / pathology
No-Observed-Adverse-Effect Level
Organ Size / drug effects
Severity of Illness Index*
Toxicity Tests / methods
Toxicity Tests / standards
United States
United States Public Health Service

Substances

Hazardous Substances