Vitamin E deficiency and impaired cellular immunity related to intestinal fat malabsorption

Gastroenterology. 1992 Jun;102(6):2139-42. doi: 10.1016/0016-5085(92)90344-x.


This report describes a patient in whom a severe vitamin E deficiency developed secondary to an intestinal malabsorptive disorder. In vivo and in vitro impairment of T-cell function, as well as a polyneuropathy, were observed in conjunction with this vitamin deficiency. Repletion of the vitamin deficiency was associated with marked improvement in the T-cell functions and modest improvement in the neuropathy. Observations in this patient suggest that severe vitamin E deficiency in humans may impair T-cell activity and that correction of the deficient state may reverse these T-cell abnormalities. Further studies will need to be performed to confirm these findings.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Fats / metabolism*
  • Female
  • Humans
  • Immunity, Cellular
  • Malabsorption Syndromes / complications*
  • Middle Aged
  • Scleroderma, Systemic / complications
  • T-Lymphocytes / immunology*
  • Vitamin E Deficiency / etiology
  • Vitamin E Deficiency / immunology*


  • Fats