Adaptor usage and Toll-like receptor signaling specificity

FEBS Lett. 2005 Jun 13;579(15):3330-5. doi: 10.1016/j.febslet.2005.04.024. Epub 2005 Apr 26.


It is now well established that Toll-like receptors (TLRs) act as primary sensors of microbial compounds. Details of the molecular mechanisms governing TLR responses are emerging steadily and our understanding of the signaling pathways activated these receptors has improved greatly over the last few years. Differences in adaptor usage, cellular localisation and signaling cascades have been elucidated. In this review we will summarize the current understanding of TLR signaling and its regulation.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Cell Membrane / metabolism
  • Gene Expression Regulation
  • Humans
  • Membrane Glycoproteins / classification
  • Membrane Glycoproteins / metabolism*
  • Receptors, Cell Surface / classification
  • Receptors, Cell Surface / metabolism*
  • Signal Transduction*
  • Substrate Specificity
  • Toll-Like Receptors


  • Adaptor Proteins, Signal Transducing
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptors