[Molecular Mechanisms of Vitamin K Action in the Bone Homeostasis]

Clin Calcium. 2005 May;15(5):839-44.
[Article in Japanese]

Abstract

Vitamin K is used as an anti-osteoporosis drug in Japan. Moreover, vitamin K intake has been found to decrease hip fracture risk. In the bone homeostasis, vitamin K action is mediated through two molecular mechanisms: posttranslational modification of proteins, and regulation of gene expression. The former is vitamin K-dependent carboxylation, in which vitamin K functions as an essential cofactor for modification of glutamic acid residues to gamma-carboxyglutamic acid residues. The latter is a novel mechanism that regulates the transcription of target genes by vitamin K through activation of steroid and xenobiotic receptor (SXR). The two mechanisms may coordinately contribute to vitamin K function in the bone metabolism.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Bone and Bones / drug effects*
  • Carboxylic Acids / metabolism
  • Glutamates / metabolism
  • Humans
  • Osteoporosis / drug therapy
  • Receptors, Steroid / physiology
  • Vitamin K / pharmacology*
  • Vitamin K / therapeutic use

Substances

  • Carboxylic Acids
  • Glutamates
  • Receptors, Steroid
  • Vitamin K