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Review
, 24 (5 Suppl), S58-61

Duration of Immunity Against Pertussis After Natural Infection or Vaccination

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Review

Duration of Immunity Against Pertussis After Natural Infection or Vaccination

Aaron M Wendelboe et al. Pediatr Infect Dis J.

Abstract

Despite decades of high vaccination coverage, pertussis has remained endemic and reemerged as a public health problem in many countries in the past 2 decades. Waning of vaccine-induced immunity has been cited as one of the reasons for the observed epidemiologic trend. A review of the published data on duration of immunity reveals estimates that infection-acquired immunity against pertussis disease wanes after 4-20 years and protective immunity after vaccination wanes after 4-12 years. Further research into the rate of waning of vaccine-acquired immunity will help determine the optimal timing and frequency of booster immunizations and their role in pertussis control.

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