Penicillin G acylase catalyzed Markovnikov addition of allopurinol to vinyl ester

Wei-Bo Wu; Na Wang; Jian-Ming Xu; Qi Wu; Xian-Fu Lin

doi:10.1039/b501338k

Penicillin G acylase catalyzed Markovnikov addition of allopurinol to vinyl ester

Chem Commun (Camb). 2005 May 14:(18):2348-50. doi: 10.1039/b501338k. Epub 2005 Mar 15.

Authors

Wei-Bo Wu¹, Na Wang, Jian-Ming Xu, Qi Wu, Xian-Fu Lin

Affiliation

¹ Department of Chemistry, Zhejiang University, Hangzhou, 310027, People's Republic of China.

PMID: 15877124
DOI: 10.1039/b501338k

Abstract

A new enzymatic process is reported, in which penicillin G acylase from Escherichia coli displays a promiscuous activity in catalyzing the Markovnikov addition of allopurinol to vinyl ester.

MeSH terms

Allopurinol / chemistry*
Catalysis
Escherichia coli / enzymology
Esters / chemistry*
Molecular Structure
Penicillin Amidase / chemistry*
Purines / chemical synthesis*
Time Factors
Vinyl Compounds / chemistry*

Substances

Esters
Purines
Vinyl Compounds
Allopurinol
Penicillin Amidase