Abstract
The title domino reactions were developed to directly provide tetrahydrofuro[3,4-c]isoxazole derivatives (5 and 9) in > or =90% ee from racemic alpha-hydroxynitrones (2 and 6), which were used in the concise asymmetric total synthesis of (-)-rosmarinecine .
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Cyclization
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Imines / chemistry*
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Kinetics
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Lipase / chemistry*
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Molecular Conformation
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Pyrrolizidine Alkaloids / chemical synthesis*
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Pyrrolizidine Alkaloids / chemistry
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Stereoisomerism
Substances
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Imines
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Pyrrolizidine Alkaloids
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rosmarinecine
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Lipase