Correlation between apoptotic endothelial microparticles and serum interleukin-6 and C-reactive protein in healthy men

Am J Cardiol. 2005 May 15;95(10):1258-60. doi: 10.1016/j.amjcard.2005.01.063.


Inflammation has been associated with increased cardiovascular risk, and endothelial cell (EC) apoptosis has been implicated in atherogenesis. The correlation between circulating concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), and endothelial microparticles (EMPs) expressing an apoptotic (EMP31) or activation (EMP62E) phenotype in 20 middle-aged healthy men was investigated. IL-6 was significantly correlated with EMP31 (r = 0.6, p = 0.004), which persisted after adjusting for body mass index and CRP. CRP was significantly correlated with body mass index (r = 0.49, p = 0.02) but not with EMP31 or EMP62E. EC apoptosis is associated with IL-6 levels in men and might be partially responsible for the increased cardiovascular risk associated with subclinical inflammation.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / blood
  • C-Reactive Protein / metabolism*
  • Cell Adhesion Molecules / metabolism*
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / diagnosis
  • Humans
  • Interleukin-6 / blood*
  • Male
  • Middle Aged
  • Reference Values


  • Biomarkers
  • Cell Adhesion Molecules
  • Interleukin-6
  • C-Reactive Protein