Aberrant expression of tumor suppressor genes and their association with chimeric oncogenes in pediatric acute lymphoblastic leukemia

Leuk Res. 2005 Nov;29(11):1271-6. doi: 10.1016/j.leukres.2005.04.006.

Abstract

Aberrant expression of tumor suppressor genes WT 1, RB 1, p53, homozygous deletion of p16 gene and their relationship with expression of oncogenes BCR-ABL, TEL-AML 1, MLL-AF 4, E2A-PBX 1, SIL-TAL 1 were determined in bone marrow samples of children with de novo B-lineage (n=170) and T-lineage (n=25) acute lymphoblastic leukemia (ALL). In contrast to expression of chimeric oncogenes alterations in p16, WT 1, RB 1 and p53 expression were T/B-lineage-unrestricted. Significant association between expression of MLL-AF 4 and WT 1, E2A-PBX 1 and p53; SIL-TAL 1 and homozygous deletion of p16 has been demonstrated.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Cell Line, Tumor
  • Child
  • Child, Preschool
  • Cyclin-Dependent Kinase Inhibitor p16 / genetics
  • Female
  • Gene Deletion
  • Gene Expression Regulation, Neoplastic*
  • Genes, Retinoblastoma / genetics
  • Genes, Tumor Suppressor*
  • Genes, Wilms Tumor
  • Genes, p53 / genetics
  • Humans
  • Infant
  • Male
  • Oncogenes / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Prognosis

Substances

  • Cyclin-Dependent Kinase Inhibitor p16