Levels of recent thymic emigrant cells decrease in children undergoing partial thymectomy during cardiac surgery

Clin Diagn Lab Immunol. 2005 May;12(5):563-5. doi: 10.1128/CDLI.12.5.563-565.2005.


The human thymus is required for establishment of a T-cell pool in fetal life, but postnatal thymectomy is not known to cause immunodeficiency. T-cell emigration from thymus (thymic recent emigrants [TRECs]) is a continuous thymic-dependent process. We studied TREC levels pre- and post-partial thymectomy in children undergoing cardiac surgery. TRECs were quantitated by real-time PCR in peripheral blood lymphocytes of 24 children (0 to 12 years). TREC values were 47916 +/- 9271 pre-partial thymectomy and 33157 +/- 8479 post-partial thymectomy in 11 paired patients (P = 0.014). Interval between pre- and post-partial thymectomy was 8.8 days +/- 5.8 days. Another group of 8 children had 30384 +/- 9748 TRECs 16 days to 6 years post-partial thymectomy. There was a significant drop in TREC values post-partial thymectomy in the immediate postoperative period compared to prethymectomy TREC levels. While decreased thymic output may persist, the long-term implications were not evaluated in this patient population.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cardiac Surgical Procedures / adverse effects*
  • Cell Movement
  • Child
  • Child, Preschool
  • Follow-Up Studies
  • Gene Rearrangement, T-Lymphocyte
  • Humans
  • Infant
  • Infant, Newborn
  • Polymerase Chain Reaction
  • Prospective Studies
  • T-Lymphocytes / immunology
  • T-Lymphocytes / physiology
  • Thymectomy / adverse effects*
  • Thymus Gland / cytology*
  • Thymus Gland / immunology