Clinical relevance of systemic and local IGF-I

Endocr Dev. 2005;9:11-16. doi: 10.1159/000085718.


The insulin-like growth factor family of ligands, receptors and binding proteins are critical for many normal physiological functions. These include normal development during fetal and post-natal development and maintenance of organ function in adult life. Circulating IGF-I is produced primarily by the liver under GH control, whereas the production of tissue IGF-I has other controls. Recent studies have demonstrated that both circulating and tissue IGF-I are important for maintaining the normal structure-function of complex organs such as bone. Circulating IGF-I is important for maintaining ambient GH levels; in its absence GH elevation is seen leading to insulin resistance. In addition, low levels of circulating IGF-I retard the progression and metastatic potential of a number of cancers.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Insulin Resistance / physiology*
  • Insulin-Like Growth Factor I / genetics
  • Insulin-Like Growth Factor I / physiology*
  • Neoplasms / genetics
  • Neoplasms / physiopathology*


  • Insulin-Like Growth Factor I