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Review
, 165 Suppl 1, S44-8

T Cell Regulation of the Antibody Response to Bacterial Polysaccharide Antigens: An Examination of Some General Characteristics and Their Implications

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Review

T Cell Regulation of the Antibody Response to Bacterial Polysaccharide Antigens: An Examination of Some General Characteristics and Their Implications

P J Baker. J Infect Dis.

Abstract

The characteristics of thymus-derived (T) lymphocytes that regulate the magnitude of the antibody response to the capsular polysaccharide antigen of type III Streptococcus pneumoniae are considered within the context of a general homeostatic model for controlling the antibody response to microbial antigens of medical importance. Some experimental approaches are described in which the activities of such regulatory T cells are modulated to provide an increase in the development of host immunity, to improve the immunogenicity of poorly immunogenic antigens, or to eliminate the inhibitory effects of suppressor T cells.

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