Dupuytren's and epilepsy revisited

J Hand Surg Br. 1992 Apr;17(2):221-4. doi: 10.1016/0266-7681(92)90095-j.


The incidence of Dupuytren's disease amongst the residents of two epileptic centres was found to be 12.0% in one and 38.1% in the other. The overall incidence at the second was significantly higher than a control population (16.0%) and this difference was particularly apparent in patients over 50 years old. The distribution of the Dupuytren's disease was found to be very similar to that of non-epileptic patients. At both centres, the disease process was more severe, with an increased incidence of contractures. Drug therapy was not clearly implicated in the aetiology of this condition.

MeSH terms

  • Adult
  • Aged
  • Anticonvulsants / administration & dosage
  • Anticonvulsants / adverse effects
  • Dupuytren Contracture / chemically induced
  • Dupuytren Contracture / epidemiology*
  • England / epidemiology
  • Epilepsy / epidemiology*
  • Female
  • Fingers / physiopathology
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Phenobarbital / administration & dosage
  • Phenobarbital / adverse effects


  • Anticonvulsants
  • Phenobarbital