Preeclampsia: a renal perspective

Kidney Int. 2005 Jun;67(6):2101-13. doi: 10.1111/j.1523-1755.2005.00316.x.


Preeclampsia is a syndrome that affects 5% of all pregnancies, producing substantial maternal and perinatal morbidity and mortality. The aim of this review is to summarize our current understanding of the pathogenesis of preeclampsia with special emphasis on the recent discovery that circulating anti-angiogenic proteins of placental origin may play an important role in the pathogenesis of proteinuria and hypertension of preeclampsia.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Female
  • HELLP Syndrome / etiology
  • Humans
  • Hypertension / etiology
  • Kidney / pathology
  • Placenta / physiology
  • Pre-Eclampsia / complications
  • Pre-Eclampsia / etiology*
  • Pregnancy
  • Proteinuria / etiology
  • Risk Factors
  • Vascular Endothelial Growth Factor A / physiology


  • Vascular Endothelial Growth Factor A