Abstract
Many countries recommend diphtheria, tetanus and/or poliomyelitis boosters in adolescents or adults and the need for pertussis booster vaccination beyond childhood is increasingly recognized. A new combined reduced-antigen-content dTpa-IPV vaccine provides booster vaccination against all four diseases in one single injection. The immunogenicity and safety of the dTpa-IPV vaccine was compared to that of licensed dTpa+IPV or Td-IPV vaccines in 806 adolescents >14 years of age and adults with a heterogeneous vaccination history. The dTpa-IPV vaccine was immunogenic and well tolerated. No clinically significant differences were observed between groups. Anti-tetanus antibody kinetics indicated that each of the vaccines could be used for tetanus prophylaxis in acute wound management. For all vaccines, the lowest post-vaccination antibody concentrations were observed in subjects >40 years of age, those seronegative prior to vaccination and those subjects whose last vaccination was > or =20 years ago. In conclusion, dTpa-IPV vaccination of subjects over 14 years of age was as immunogenic and well tolerated as the licensed dTpa+IPV or Td-IPV vaccines. Vaccination coverage of adults is poor and the use of combined vaccines such as dTpa-IPV during vaccination visits, or for wound management, maximizes opportunities for boosting in these difficult to reach age groups.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Adolescent
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Adult
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Aged
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Aging
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Antibodies, Bacterial / blood
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Antibodies, Viral / blood
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Diphtheria / prevention & control
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Diphtheria Toxoid / administration & dosage
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Diphtheria Toxoid / adverse effects*
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Diphtheria Toxoid / immunology*
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Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage
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Diphtheria-Tetanus-Pertussis Vaccine / adverse effects*
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Diphtheria-Tetanus-Pertussis Vaccine / immunology*
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Diphtheria-Tetanus-acellular Pertussis Vaccines / immunology
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Female
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France
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Germany
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Humans
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Immunization, Secondary*
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Male
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Middle Aged
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Pertussis Vaccine / administration & dosage
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Pertussis Vaccine / adverse effects*
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Pertussis Vaccine / immunology*
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Poliomyelitis / prevention & control
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Poliovirus Vaccine, Inactivated / administration & dosage
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Poliovirus Vaccine, Inactivated / adverse effects*
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Poliovirus Vaccine, Inactivated / immunology*
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Tetanus / prevention & control
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Tetanus Toxoid / administration & dosage
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Tetanus Toxoid / adverse effects*
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Tetanus Toxoid / immunology*
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Vaccines, Combined / administration & dosage
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Vaccines, Combined / adverse effects
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Vaccines, Combined / immunology
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Whooping Cough / prevention & control
Substances
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Antibodies, Bacterial
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Antibodies, Viral
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DTPP vaccine
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Diphtheria Toxoid
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Diphtheria-Tetanus-Pertussis Vaccine
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Diphtheria-Tetanus-acellular Pertussis Vaccines
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Pertussis Vaccine
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Poliovirus Vaccine, Inactivated
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Tetanus Toxoid
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Vaccines, Combined