Multicomponent Lyme vaccine: three is not a crowd

Vaccine. 2005 May 25;23(28):3687-96. doi: 10.1016/j.vaccine.2005.02.006.

Abstract

Lyme disease is caused by the spirochete Borrelia burgdorferi and it is the most common vector-borne disease in the United States. Disseminated spirochetes can persist in various tissues and can result in a variety of different disease manifestations. Vaccination trials testing various lipoprotein candidates have yielded mixed results despite the generation of robust antibody titers. Data presented in this report demonstrate that a combination vaccine composed of DbpA, BBK32 and OspC is more effective than single or double component formulations and that the ratio of each component dramatically impacts vaccine efficacy when tested in protection experiments against Borrelia following needle inoculation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adhesins, Bacterial / administration & dosage
  • Adhesins, Bacterial / immunology
  • Animals
  • Antibodies, Bacterial / blood*
  • Antigens, Bacterial / administration & dosage
  • Antigens, Bacterial / immunology
  • Bacterial Outer Membrane Proteins / administration & dosage
  • Bacterial Outer Membrane Proteins / immunology
  • Bacterial Proteins / administration & dosage
  • Bacterial Proteins / immunology
  • Borrelia burgdorferi / immunology*
  • Disease Models, Animal
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Immunoglobulin G / blood
  • Lyme Disease / prevention & control*
  • Lyme Disease Vaccines / administration & dosage
  • Lyme Disease Vaccines / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Vaccines, Subunit / administration & dosage
  • Vaccines, Subunit / immunology
  • Vaccines, Synthetic / administration & dosage
  • Vaccines, Synthetic / immunology

Substances

  • Adhesins, Bacterial
  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Bacterial Outer Membrane Proteins
  • Bacterial Proteins
  • DdpB protein, Borrelia burgdorferi
  • Immunoglobulin G
  • Lyme Disease Vaccines
  • OspC protein
  • Vaccines, Subunit
  • Vaccines, Synthetic
  • p35 antigen, Borrelia