Neonatal lupus erythematosus presenting with cholestatic hepatitis: a case report and review of the literature

Turk J Pediatr. 2005 Jan-Mar;47(1):63-6.

Abstract

Neonatal lupus erythematosus (NLE) is a disease primarily characterized by cardiac and/or cutaneous involvement. Hepatic, hematological, neurological and pulmonary involvement are rare manifestations and normally considered as mild and transient complications. But recent studies have shown more frequent hepatic involvement in NLE. We report a two month-old male infant, born to a clinically asymptomatic mother, presenting with significant hepatic involvement and annular, erythematous plaques with hyperkeratotic borders at the eyebrow region and anterior surface of trunk. Both the infant and his mother were positive for anti-Ro (SS-A) and anti-La (SS-B).

Publication types

  • Case Reports
  • Review

MeSH terms

  • Alanine Transaminase / blood
  • Antibodies, Antinuclear / blood
  • Bilirubin / blood
  • Cholestasis, Intrahepatic / etiology*
  • Glutamyl Aminopeptidase / blood
  • Humans
  • Hyperkeratosis, Epidermolytic / blood
  • Infant, Newborn
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / drug therapy
  • Lupus Erythematosus, Systemic / immunology
  • Male
  • Prognosis
  • Steroids / administration & dosage
  • Steroids / therapeutic use
  • Treatment Outcome

Substances

  • Antibodies, Antinuclear
  • Steroids
  • Alanine Transaminase
  • Glutamyl Aminopeptidase
  • Bilirubin