Lymphocyte subsets, TNF alpha and interleukin-4 levels in treated and untreated subacute sclerosing panencephalitis patients

J Neuroimmunol. 2005 Jun;163(1-2):195-8. doi: 10.1016/j.jneuroim.2005.02.014. Epub 2005 Apr 12.


Immunologic studies in relation to clinical status might help to understand the pathogenesis of subacute sclerosing panencephalitis (SSPE) and the effect of treatment. We measured lymphocyte subsets and intracellular TNFalpha and interleukin-4 levels in peripheral blood in SSPE patients. Patients had elevated percentages of CD8+ cells compared to age-matched control children. Rapidly progressive course was associated with increased CD4+ cells. Treatment with interferons and inosiplex altered the percentage of CD3+, CD4+ and CD19+ cells. TNFalpha and interleukin-4 levels had no correlation with course or treatment. The proportions of lymphocyte subsets appear to have a role in the evolution or manifestations of SSPE, if not in the pathogenesis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Inosine Pranobex / therapeutic use
  • Interferons / therapeutic use
  • Interleukin-4 / blood*
  • Lymphocyte Subsets / immunology
  • Lymphocyte Subsets / metabolism*
  • Male
  • Subacute Sclerosing Panencephalitis / drug therapy*
  • Subacute Sclerosing Panencephalitis / immunology*
  • Tumor Necrosis Factor-alpha / metabolism*


  • Tumor Necrosis Factor-alpha
  • Interleukin-4
  • Interferons
  • Inosine Pranobex