Calvarial metastases as clinical presentation of renal cell carcinoma: report of two cases and review of the literature

Clin Neurol Neurosurg. 2005 Jun;107(4):329-33. doi: 10.1016/j.clineuro.2004.07.017.


Calvarium is a frequent target site of involvement for common neoplasms. Some cases of calvarial metastases have been reported in literature as secondary lesions from renal cell carcinoma (RCC), but only five cases have been described concerning calvarial mass as the first clinical presentation of this kind of tumor. In this report, we discuss the clinical aspects of two further cases we observed, in which the renal cell carcinoma was found thanks to the histological examination of a calvarial mass after surgery. We also briefly review the literature.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Carcinoma, Renal Cell / diagnosis
  • Carcinoma, Renal Cell / secondary*
  • Carcinoma, Renal Cell / surgery
  • Female
  • Frontal Bone* / surgery
  • Humans
  • Kidney Neoplasms / pathology*
  • Male
  • Middle Aged
  • Occipital Bone* / surgery
  • Skull Neoplasms / diagnosis
  • Skull Neoplasms / secondary*
  • Skull Neoplasms / surgery