CD27 and CD70 in T cell and B cell activation

Curr Opin Immunol. 2005 Jun;17(3):275-81. doi: 10.1016/j.coi.2005.04.004.


In vitro work has defined the TNF receptor family member CD27 as a T and B cell co-stimulatory molecule. Its activity is governed by the transient availability of its TNF-like ligand CD70 on lymphocytes and dendritic cells. Recent studies, enforcing or abrogating CD27 function by genetic or protein intervention in mouse models have revealed key contributions of the CD27-CD70 system to effector and memory T cell formation, which is probably based on improved cell survival. The stimulatory effects of CD27 on B cell function appear to oppose those of CD70, which also has a signaling role. Targeting CD27-CD70 for therapy is attractive but should take into account the fact that constitutive CD27 stimulation culminates in lethal immunodeficiency.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD / metabolism*
  • B-Lymphocytes / immunology*
  • CD27 Ligand
  • Humans
  • Lymphocyte Activation / immunology*
  • Membrane Proteins / metabolism*
  • Mice
  • T-Lymphocytes / immunology*
  • Tumor Necrosis Factor Receptor Superfamily, Member 7 / metabolism*


  • Antigens, CD
  • CD27 Ligand
  • CD70 protein, human
  • Cd70 protein, mouse
  • Membrane Proteins
  • Tumor Necrosis Factor Receptor Superfamily, Member 7