The role of CD22 and other inhibitory co-receptors in B-cell activation

Curr Opin Immunol. 2005 Jun;17(3):290-7. doi: 10.1016/j.coi.2005.03.005.


Inhibitory co-receptors downmodulate B-cell receptor (BCR) signalling by setting a signalling threshold that prevents overstimulation of B cells. Activation of these inhibitory co-receptors occurs by phosphorylation on their cytoplasmic inhibitory immunoreceptor tyrosine-based inhibition motifs (ITIMs), followed by recruitment of the tyrosine phosphatase SHP-1 or the lipid phosphatase SHIP, and depends on their association with the BCR. Recent evidence shows that B-cell signal inhibition is regulated by ligand binding of inhibitory receptors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD / metabolism*
  • Antigens, Differentiation, B-Lymphocyte / metabolism*
  • B-Lymphocytes / immunology*
  • Cell Adhesion Molecules / metabolism*
  • Humans
  • Lectins / metabolism*
  • Lymphocyte Activation / immunology*
  • Mice
  • Receptors, Antigen, B-Cell / metabolism*
  • Receptors, Immunologic / metabolism
  • Sialic Acid Binding Ig-like Lectin 2
  • Signal Transduction


  • Antigens, CD
  • Antigens, Differentiation, B-Lymphocyte
  • CD22 protein, human
  • Cd22 protein, mouse
  • Cell Adhesion Molecules
  • Lectins
  • Receptors, Antigen, B-Cell
  • Receptors, Immunologic
  • Sialic Acid Binding Ig-like Lectin 2