The Role of Epidural Spinal Cord Stimulation in the Treatment of Buerger's Disease

J Vasc Surg. 2005 May;41(5):830-6. doi: 10.1016/j.jvs.2005.01.044.


Purpose: This clinical, retrospective study is evaluated the effect of epidural spinal cord stimulation (SCS) in the treatment of Buerger's disease.

Methods: The clinical criteria of Shionoya were used to diagnose 29 patients (22 men, 7 women; mean age 33.7 years) with Buerger's disease. The patients underwent SCS. Complete physical examination and vascular laboratory data were available and recorded for all patients. Questions regarding the improvement of symptoms, in lifestyle, and in physical activities were asked direct interview or by telephone during mean follow-up of 4 years.

Results: The regional perfusion index (RPI), the ratio between the foot and chest transcutaneous oxygen pressure at baseline (before SCS treatment) was 0.27 +/- 0.25. Three months after SCS implantation the RPI increased to 0.41 +/- 0.22. During the follow-up period, a sustained improvement in microcirculation was recorded: the RPI at 1-year follow-up was 0.49 +/- 0.34 and at 3-year follow-up was 0.52 +/- 0.21. The most pronounced improvement in the RPI values was found in the subgroup of 13 patients with trophic lesions. In this group, the RPI increased significantly from 0.17 +/- 0.21 to 0.4 +/- 0.18 (P < .023) after a mean follow-up of 5.7 years. Two patients underwent major amputation of the lower target limb. The limb survival rate was 93.1%. During the follow-up period of 4 years, 21 of the 29 patients continued to smoke, and only five patients stopped nicotine exposure.

Conclusions: We recorded a significant benefit in the microcirculation, a good limb survival rate, and the absence of new trophic lesions. During the follow-up period, no severe complications related to the implanted devices occurred. Because of the diffuse, distal, segmental nature of the disease, SCS should be considered as an alternative treatment modality in patients with Buerger's disease.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Amputation / statistics & numerical data
  • Blood Gas Monitoring, Transcutaneous
  • Electric Stimulation Therapy / methods*
  • Epidural Space*
  • Female
  • Follow-Up Studies
  • Humans
  • Leg / blood supply*
  • Male
  • Microcirculation / physiology
  • Regional Blood Flow / physiology
  • Retrospective Studies
  • Thromboangiitis Obliterans / blood
  • Thromboangiitis Obliterans / physiopathology
  • Thromboangiitis Obliterans / therapy*
  • Treatment Outcome
  • Walking / physiology