ETV6 gene rearrangements in invasive breast carcinoma

Genes Chromosomes Cancer. 2005 Sep;44(1):103-8. doi: 10.1002/gcc.20200.

Abstract

The ETV6/TEL gene encodes a transcription factor frequently rearranged in several types of cancer. We looked for ETV6 rearrangements in invasive breast cancer using fluorescence in situ hybridization (FISH) of BAC probes on sections of tissue microarrays containing 632 tumor samples. Of these samples, signal of sufficient quality for screening by FISH was obtained for 356. Five cases (one lobular, one nontypical secretory, one mixed, and two ductal carcinomas) showed ETV6 rearrangement.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / genetics
  • Adult
  • Aged
  • Aged, 80 and over
  • Artificial Gene Fusion
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology
  • Centromere / genetics
  • Chromosome Mapping
  • DNA-Binding Proteins / genetics*
  • Female
  • Gene Rearrangement
  • Humans
  • In Situ Hybridization, Fluorescence
  • Middle Aged
  • Neoplasm Invasiveness
  • Nuclear Proteins / genetics*
  • Proto-Oncogene Proteins c-ets
  • Repressor Proteins / genetics*
  • Telomere / genetics

Substances

  • DNA-Binding Proteins
  • ETS translocation variant 6 protein
  • Nuclear Proteins
  • Proto-Oncogene Proteins c-ets
  • Repressor Proteins