The Next Generation of Phosphodiesterase Inhibitors: Structural Clues to Ligand and Substrate Selectivity of Phosphodiesterases

J Med Chem. 2005 May 19;48(10):3449-62. doi: 10.1021/jm040217u.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Crystallography, X-Ray
  • Cyclic AMP / metabolism
  • Cyclic GMP / metabolism
  • Drug Design
  • Humans
  • Models, Molecular
  • Molecular Structure
  • Phosphodiesterase Inhibitors / chemical synthesis
  • Phosphodiesterase Inhibitors / chemistry*
  • Phosphodiesterase Inhibitors / metabolism
  • Quantitative Structure-Activity Relationship
  • Xanthines / chemistry

Substances

  • Phosphodiesterase Inhibitors
  • Xanthines
  • Cyclic AMP
  • Cyclic GMP