STAT4: a critical regulator of inflammation in vivo

Immunol Res. 2005;31(3):231-42. doi: 10.1385/IR:31:3:231.


Signal transducer and activator of transcription 4 (STAT4) is a central mediator in generating inflammation during protective immune responses and immune-mediated diseases. In the 8 yr since their first description, STAT4-deficient mice have defined the role of STAT4 in a variety of in vivo model systems. Despite the extensive study and use of these mice, the exact role of STAT4 in vivo is still unclear. In this review, I focus on describing the phenotypes of STAT4-deficient immune responses to pathogens and in diseases. Comparing the effects of STAT4 deficiency among numerous model systems will further enhance the development of a systemic model of STAT4 function in vivo.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology
  • Bacterial Infections / immunology
  • Cytokines / biosynthesis
  • Hematopoiesis
  • Histocompatibility Antigens Class II / immunology
  • Hypersensitivity / immunology
  • Immune Tolerance
  • Inflammation / immunology*
  • Mice
  • Mice, Knockout
  • Neoplasms / immunology
  • Parasitic Diseases / immunology
  • STAT4 Transcription Factor / genetics
  • STAT4 Transcription Factor / physiology*
  • Signal Transduction
  • Transplantation Immunology
  • Virus Diseases / immunology


  • Cytokines
  • Histocompatibility Antigens Class II
  • STAT4 Transcription Factor